CHARGE Results

CHARGE Results in dbGaP

CHARGE Consortium working groups may release summary data from genome-wide meta analyses to allow the scientific community to examine associations of variants or loci of their interest for association with these traits. The files typically include p-values and direction of effect for millions of genotyped or imputed single nucleotide polymorphisms (SNPs). Some of these results are now available via dbGaP, where association results can be viewed in the Genome Browser and full summary statistics can be downloaded via authorized access. 

A further description is available in a Correspondence to Nature Genetics : 

Rapid evaluation of phenotypes, SNPs and results through the dbGaP CHARGE Summary Results site.

Stephen S Rich, Zeng Y Wang, Anne Sturcke, Lora Ziyabari, Mike Feolo, Christopher J O'Donnell, Ken Rice, Joshua C Bis, Bruce M Psaty

Nature Genetics 48, 702–703 (2016) doi:10.1038/ng.3582 (Published online 28 June 2016)

Blood Cell Traits

Incident Coronary Heart Disease

Anti-hypertensive medications and risk of CVD

Pulmonary
Fatty Acids

Other results, posted via alternative mechanisms are also listed on this page.  A brief description of the traits and analytic methods, the relevant citation(s) for the source publication, as well as instructions for acknowledging the data is provided below, per dataset. 

Other CHARGE Results

CHARGE Fatty Acids Working Group

N-3 Fatty Acids Association Results

Association results of circulating levels of four n-3 fatty acids were available for up to 8,866 adults of European descent from 5 GWAS and combined using inverse-variance meta-analysis.

If these results are helpful to you, please cite:

  • Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.  Lemaitre RN et al.   PLoS Genetics 2011;7(7); e1002193. doi:10.1371/journal.pgen.1002193

Four files with association results for ALA (18:3n3), EPA (20:5n3), DPA (22:5n3) and DHA (22:6n3) can be downloaded.


Very Long-Chain Saturated Fatty Acids Association Results

Association results of circulating levels of three very long-chain saturated fatty acids were available for up to 10,129 adults of European descent from 7 GWAS and combined using a z score–based meta-analysis.

If these results are helpful to you, please cite:

  • Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids. Lemaitre RN et al.  J. Lipid Res. 201;56:176-84. 

·         Three files with association results for 20:0 (arachidic acid), 22:0 (behenic acid) and 24:0 (lignoceric acid) can be downloaded:

Please note that z-score-based meta-analyses do not provide estimates of the size of the associations. The direction of the associations is provided by the sign of the z-score.


Trans-Fatty Acids Association Results

Association results of circulating levels of 5 trans-fatty acids were available for up to 8,013 adults of European descent from 7 GWAS, and combined using fixed-effect meta-analysis.

If these results are helpful to you, please cite:

  • Genetic loci associated with circulating  phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. Mozaffarian D et al. AJCN 2015;101:398-406.

Five files with association results for trans-16:1n7, trans-18:1 (sum of 5 isomers), cis, trans-18:2, trans, cis-18:2  and trans, trans-18:2, can be downloaded:


N-6 Fatty Acids Association Results

Association results of circulating levels of 5 n-6 fatty acids were available for up to 8631 adults of European descent from 5 GWAS, and combined using fixed-effect meta-analysis.

If these results are helpful to you, please cite:

  • Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.  Guan W et al. Circ Cardiovasc Genet.2014;7:321-31.

Five files with association results for 18:2n6 (linoleic acid), 18:3n6 (gamma-linolenic acid), 20:3n6 (dihomo-gamma-linolenic acid), 20:4n6 (arachidonic acid) and 22:4n6 (adrenic acid) can be downloaded from:

            http://www.msi.umn.edu/~guanw0/CHARGE_N6GWAS/


Fatty Acids from de novo lipogenesis pathway - Association Results

Association results of circulating levels of 4 fatty acids were available for up to 8961 adults of European descent from 5 GWAS, and combined using fixed-effect meta-analysis.

    If these results are helpful to you, please cite:

    • Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.  Wu JH et al. Circ Cardiovasc Genet.2013;6:171-83.

    Four files with association results for 16:0 (palmitic acid), 18:0 (stearic acid), 16:1n7 (palmitoleic acid), and 18:1n9 (oleic acid) can be downloaded from:


    Send questions about this workspace to ROZENN N. LEMAITRE.