CHARGE Results

CHARGE Results in dbGaP

CHARGE Consortium working groups may release summary data from genome-wide meta analyses to allow the scientific community to examine associations of variants or loci of their interest for association with these traits. The files typically include p-values and direction of effect for millions of genotyped or imputed single nucleotide polymorphisms (SNPs). Some of these results are now available via dbGaP accession phs000930, where association results can be viewed in the Genome Browser and full summary statistics can be downloaded via authorized access.

A further description is available in a Correspondence to Nature Genetics :

Rapid evaluation of phenotypes, SNPs and results through the dbGaP CHARGE Summary Results site.

Stephen S Rich, Zeng Y Wang, Anne Sturcke, Lora Ziyabari, Mike Feolo, Christopher J O'Donnell, Ken Rice, Joshua C Bis, Bruce M Psaty

Nature Genetics 48, 702–703 (2016) doi:10.1038/ng.3582 (Published online 28 June 2016)

The list of available traits increases quarterly. A current list of available analyses can be found by browsing dbGaP. A sample of initial analysis results is listed below.

CHARGE_phs000930.v8.p1_results

Other CHARGE Results

CHARGE Fatty Acids Working Group

Posted files from the CHARGE Fatty Acids Working Group are comprehensive meta-analysis results of GWAS of fatty acid levels, without any exclusion. The published reports typically excluded SNPs associated with fatty acids in a single cohort, and SNPs with minor allele frequency < 1%.

N-3 Fatty Acids Association Results

Association results of circulating levels of four n-3 fatty acids were available for up to 8,866 adults of European descent from 5 GWAS and combined using inverse-variance meta-analysis.

If these results are helpful to you, please cite:

- Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. Lemaitre RN et al. PLoS Genetics 2011;7(7); e1002193. doi:10.1371/journal.pgen.1002193

Four files with association results for ALA (18:3n3), EPA (20:5n3), DPA (22:5n3) and DHA (22:6n3) can be downloaded.

- ALA association results: http://faculty.washington.edu/rozenl/files/CHARGE_N3_ALA.txt

EPA association results: http://faculty.washington.edu/rozenl/files/CHARGE_N3_EPA.txt
DPA association results: http://faculty.washington.edu/rozenl/files/CHARGE_N3_DPA.txt
DHA association results: http://faculty.washington.edu/rozenl/files/CHARGE_N3_DHA.txt

Very Long-Chain Saturated Fatty Acids Association Results

Association results of circulating levels of three very long-chain saturated fatty acids were available for up to 10,129 adults of European descent from 7 GWAS and combined using a z score–based meta-analysis.

If these results are helpful to you, please cite:

- Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids. Lemaitre RN et al. J. Lipid Res. 201;56:176-84.

Five files with association results for 20:0 (arachidic acid), 22:0 (behenic acid) and 24:0 (lignoceric acid) can be downloaded:

20:0 association results: http://faculty.washington.edu/rozenl/files/CHARGE_20_0.txt
22:0 association results: http://faculty.washington.edu/rozenl/files/CHARGE_22_0.txt
22:0 association results from analyses adjusted for 20:0: http://faculty.washington.edu/rozenl/files/CHARGE_22_0_adjfor200.txt
24:0 association results:http://faculty.washington.edu/rozenl/files/CHARGE_24_0.txt
24:0 association results from analyses adjusted for 20:0: http://faculty.washington.edu/rozenl/files/CHARGE_24_0_adjfor200.txt

Please note that z-score-based meta-analyses do not provide estimates of the size of the associations. The direction of the associations is provided by the sign of the z-score.

Trans-Fatty Acids Association Results

Association results of circulating levels of 5 trans-fatty acids were available for up to 8,013 adults of European descent from 7 GWAS, and combined using fixed-effect meta-analysis.

If these results are helpful to you, please cite:

- Genetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. Mozaffarian D et al. AJCN 2015;101:398-406.

Five files with association results for trans-16:1n7, trans-18:1 (sum of 5 isomers), cis, trans-18:2, trans, cis-18:2 and trans, trans-18:2, can be downloaded:

trans-16:1n7 association results: http://faculty.washington.edu/rozenl/files/T16_1n7_July5_1.txt
trans-18:1 association results: http://faculty.washington.edu/rozenl/files/T18_1_July5_1.txt
cis, trans-18:2 association results: http://faculty.washington.edu/rozenl/files/T18_2_ct_July5_1.txt
trans, cis-18:2 association results: http://faculty.washington.edu/rozenl/files/T18_2_tc_July5_1.txt
trans, trans-18:2 association results: http://faculty.washington.edu/rozenl/files/T18_2_tt_July5_1.txt

N-6 Fatty Acids Association Results

Association results of circulating levels of 5 n-6 fatty acids were available for up to 8631 adults of European descent from 5 GWAS, and combined using fixed-effect meta-analysis.

If these results are helpful to you, please cite:

- Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. Guan W et al. Circ Cardiovasc Genet.2014;7:321-31.

Five files with association results for 18:2n6 (linoleic acid), 18:3n6 (gamma-linolenic acid), 20:3n6 (dihomo-gamma-linolenic acid), 20:4n6 (arachidonic acid) and 22:4n6 (adrenic acid) can be downloaded from:

18:2n6 association results: http://faculty.washington.edu/rozenl/files/N6meta182.txt
18:3n6 association results: http://faculty.washington.edu/rozenl/files/N6meta183.txt
20:4n6 association results: http://faculty.washington.edu/rozenl/files/N6meta204.txt
20:3n6 association results: http://faculty.washington.edu/rozenl/files/N6meta203.txt
22:4n6 association results: http://faculty.washington.edu/rozenl/files/N6meta224.txt

Fatty Acids from de novo lipogenesis pathway - Association Results

Association results of circulating levels of 4 fatty acids were available for up to 8961 adults of European descent from 5 GWAS, and combined using fixed-effect meta-analysis.

If these results are helpful to you, please cite:

- Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Wu JH et al. Circ Cardiovasc Genet.2013;6:171-83.

Four files with association results for 16:0 (palmitic acid), 18:0 (stearic acid), 16:1n7 (palmitoleic acid), and 18:1n9 (oleic acid) can be downloaded from:

16:0 association results:http://faculty.washington.edu/rozenl/files/CHARGE_160.txt
18:0 association results:http://faculty.washington.edu/rozenl/files/CHARGE_180.txt
16:1n7 association results: http://faculty.washington.edu/rozenl/files/CHARGE_161n7.txt
18:1n9 association results: http://faculty.washington.edu/rozenl/files/CHARGE_181n9.txt

Odd Chain Saturated Fatty Acids - Association Results

Fixed effect meta-analysis of GWAS results for 5 fatty acids/ sum of fatty acids.

If these results are helpful to you, please cite:

Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids: results from the CHARGE Consortium.
- de Oliveira Otto MC et al. PLoS ONE 13(5): e0196951. https://doi.org/10.1371/journal.pone.0196951.

Five files with association results for 15:0, 17:0, sum of 15:0 and 17:0, 19:0 and 23:0 can be downloaded from:

15:0 association results: http://faculty.washington.edu/rozenl/files/150.txt
17:0 association results: http://faculty.washington.edu/rozenl/files/170.txt
Sum 15:0+17:0 association results: http://faculty.washington.edu/rozenl/files/Sum150170.txt
19:0 association results: http://faculty.washington.edu/rozenl/files/190.txt
23:0 association results: http://faculty.washington.edu/rozenl/files/230.txt

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