Workshop: 1:00 - 5:00, Crystal Ballroom (3rd Floor)

Insights from the NIH All of Us Research Program - A Comprehensive Journey through Emerging Scientific Findings, Cross-Cohort Analyses, and Genomic Discovery

Convener: Josh Denny (All of Us Research, NIH)

Genomic and other data are broadly available in the cloud-based platform, the All of Us Researcher Workbench. Here, researchers have discovered >275M previously unreported genetic variants, identified from data shared by nearly 250,000 All of Us participants. This extensive dataset, enriched with non-European genetic ancestry, opens new avenues for understanding genetic influences on health. Join us to delve into the emerging scientific impact and cross-cohort analyses.

Overview of All of Us  Josh Denny (All of Us Research, NIH)

BP PRS in All of Us  Jacob Keaton (Denny Lab)

Clopidogrel & CYP2C19  Peter Sauer (Denny Lab)

T2D and OmicsPred PheWAS  Henry Taylor (Collins lab)

Panel Q&A

Break (30 min)

APOL1 risk variants in All of Us  Ariel Williams (Denny Lab)

Rare variants/PheRS  Chenjie Zeng (Denny Lab)

Multiple Sclerosis  Mary Davis (Brigham Young University)

Panel Q&A

Evening Social Activity: 6:15ish, Stout St Social, 1400 Stout St

Informal meet-up at Stout St. Social, next to the Embassy Suites. Open to all and no sign-up required. Meet in the lobby at 6:00 to walk over or meet us there 

Working Group Meetings 8:00 - 11:50 

8:00- 8:50: 

• Lipids Crystal Ballroom (3rd Floor)

• Hemostasis Crestone A (3rd Floor)

• Neurology Crestone B (3rd Floor)

9:00: 

• Polygenic Risk Crystal Ballroom (3rd Floor)

• Monet Multi-Omic Workshop Crestone A (3rd Floor)

• Neurology Crestone B (3rd Floor)

10:00: 

• CHD/Athero Crystal Ballroom (3rd Floor)

• Microbiome Crestone B (3rd Floor)

• Gene-Lifestyle Crestone A (3rd Floor) 10:00 - 11:30 

11:00: 

• Proteomics Crystal Ballroom (3rd Floor)

11:30 – 1:00  Lunch Cripple Creek Ballroom (2nd Floor)

Congress Session Crystal Ballroom (3rd Floor)

1:00 – 1:05   Welcome Leslie Lange (University of Colorado Anschutz)

1:05 – 1:15  State of CHARGE Jennifer Huffman (Palo Alto Veterans Institute for Research / Harvard Medical School)

Session 1 Moderators: Chris Gignoux (University of Colorado Anschutz) and George Papanicolaou (NIH)

1:15 – 1:40  Genome of Europe project  André Uitterlinden (Erasmus MC)

1:40 – 2:05  Updates from the TOPMed Multi-Omics Working Group  Laura Raffield (University of North Carolina)

2:05 – 2:20  Cross-Population Comparison of Aptamer and Antibody Proteomics Measures  Jayna Nicholas (University of North Carolina)

2:20 – 2:35  The Impact of Long-term Exposure to Air Pollution on Plasma Proteomic and Metabolomic Profiles in UK Biobank  Daeeun Kim (UNC)

2:35 – 2:50  Constructing and Evaluating Omic Risk Scores for Chronic Obstructive Pulmonary Disease-Related Traits  Iain Konigsberg (University of Colorado)

2:50 – 3:15  Refreshment Break   3rd Floor Foyer

Session 2 Moderators: Ronit Yarden (NHLBI) and Sridharan Raghavan (University of Colorado Anschutz)

3:15 – 3:40  Building infrastructure to assess the pathobiology of health disparities  Gladys Maestre (University of Texas Rio Grande Valley)

3:40 – 4:05  Challenges and opportunities working with aging phenotypes  Kathryn Lunetta (Boston University)

4:05 - 4:20  RAB5C regulation of VWF secretion  Paula Reventun (Johns Hopkins University)

4:20 - 4:35  Serum proteomics reveal APOE-dependent and independent protein signatures in Alzheimer's disease Valborg Gudmundsdottir (Icelandic Heart Assoc)

Poster Blitz Ringleader: Maggie Stanislawski (University of Colorado Anschutz)

4:35 – 5:00  One-minute oral abstract presentations

• • The drug development paradigm – an ecosystem primed for disruption through human genetics.  Dipender Gill

  • Influence of Longitudinal Proteomic Trajectories on Cardiac Structure and Function in the Atherosclerosis Risk in Communities (ARIC) Study  Madeline Gillman

  • Identifying common and rare variants associated with cardiac structure and function by whole genome sequencing  Shinhye Chung

  • Platelet RNA-Seq Reveals Differentially Expressed Genes in Participants of the Framingham Heart Study with Type 2 Diabetes and Obesity  Sara Yi

  • A Large-Scale Genome-Wide Meta-analysis of Gene-Smoking Interactions for Blood Pressure in 1 Million Individuals Identifies Multiple Novel Loci  Mengyu Zhang

  • Utilizing sex-specific polygenic risk to prognosticate coronary artery disease in women  Kaavya Paruchuri

  • Calibration of Polygenic Risk Scores in African Americans using Estimated Genetic Ancestry  Luciana B. Vargas

  • Integrating PRS and ten-year atherosclerotic cardiovascular disease (ASCVD) risk scores in REGARDS  Mariah Meyer

  • Development and validation of a rank ordered educational variable in the Million Veterans Program (MVP) and the UK Biobank (UKBB) – A CHARGE consortium pilot study  Nataraja Sarma Vaitinadin

  • Metabolomic Associations with Lung Function Indices and Chronic Obstructive Pulmonary Disease in Multi-ancestral Populations  Yura Lee

  • DNA methylation variation in hematopoietic stem cells and other blood cells may impact platelet function  Jillian Teichman

  • Circulating Immune Cells are Associated with Brain MRI Measurements in the Framingham Offspring  Yumeng Cao

  • The Influence of Vitamin D on Memory Recall and Word Intrusion: Variations Across Ethnic and Income Groups. NHANES 2011-2014 Study.  Juan C Lopez-Alvarenga

  • Immune Cell Phenotypes and Inflammatory Proteins are Associated with Future DNA Methylation Measures of Healthy Biological Aging: Framingham Heart Study Offspring Cohort  Lia Rotti

  • Leveraging the Genetics of Dietary Intake to Achieve Precision Nutrition  Kristen J Sutton

  • Obesity Genetic Risk Scores and Weight Loss in Participants from the Daily Caloric Restriction versus Intermittent Fasting Trial (DRIFT)  Emily Yeo

  • Dissecting ancestry-aware molecular causal paths of type 2 diabetes  Satoshi Yoshiji

  • Association of Polygenic Risk Scores with Aortic Valve Calcium: The Multi-Ethnic Study of Atherosclerosis (MESA)  Seamus Whelton

  • Genetics and Context for Precision Health in Greater Boston  Satoshi Koyama

Poster Reception 6:00 - 8:00  Silverton Ballroom (2nd Floor)

Peruse posters while enjoying hors d'oeuvres. A no-host bar will be available to purchase beverages.  

Congress Session Crystal Ballroom (3rd Floor)

Session 3 Moderators: Ye Yan (NHLBI) and Vasan Ramachandran (University of Texas Health Sciences Center, San Antonio)

8:30 – 8:55 Trans-Omic Analyses in Heart Failure  Matthew Taylor (University of Colorado Anschutz)

8:55 – 9:20 How natural selection shapes what we find in GWAS  Jonathan Pritchard (Stanford University)

9:20 – 9:45 The role of sex in the genetics and genomics of complex traits in humans  Barbara Stranger (Northwestern University)

9:45 – 10:00 Contemporary Polygenic Scores of Low-Density Lipoprotein Cholesterol and Coronary Artery Disease Predict Coronary Atherosclerosis in Adolescents and Young Adults  Themistocles Assimes (Stanford University)

10:00 – 10:10  Tiger Awards Ceremony Presented by Josh Bis and Alanna Morrison on behalf of the CHARGE Research Steering Committee

10:10 – 10:30 Refreshment Break   3rd Floor Foyer

Session 4 Moderators: Joanne Cole (University of Colorado Anschutz) and Fernando Rivadeneira (Erasmus Medical Center)

10:30 – 10:55  Advancing data-driven biology to unravel complex disease mechanisms  Arjun Krishnan (University of Colorado Anschutz Medical Campus)

10:55 – 11:20  How should we visualize heterogeneity in meta-analyses? Have your say!  Ken Rice (University of Washington)

11:20 – 11:35  AladynIndividual: Capturing Individual Informed Latent Disease Trajectories  across time and genomic profiles Sarah Urbut (Mass General)

11:35 – 11:50  Evaluating off-target drug effects seen in RCTs using proteomics and Mendelian randomization  Jennifer A Brody (University of Washington)

 11:50 – 12:00   Closing remarks Leslie Lange (University of Colorado Anschutz)

12:00 – 1:00  Lunch Cripple Creek Ballroom (2nd Floor)

Workshop: 1:00 - 3:30, Crystal Ballroom (3rd Floor) Open to all registered attendees.

Genomic research in the All of Us Researcher Workbench

Led by: Mary Davis (Brigham Young University) and Megan He (Vanderbilt University Medical Center)

A 2.5 hour session delving into how to utilize genomic data within the All of Us Researcher Workbench. Attendees will be able to actively learn through presenter led hands on activities. 

This workshop will be most beneficial to data scientists, bioinformaticians, health services researchers, epidemiologists, and genomics researchers at the introductory or intermediate level. It is recommended that attendees have basic familiarity with using R and/or Python programming languages and a working knowledge of basic genetic association study concepts and prior experience running a genetic association analysis. It is recommended that attendees bring a laptop and register with the All of Us Research Program (https://www.researchallofus.org/register/) prior to the start of the workshop to participate in all activities.

Welcome and overview of All of Us  Mary Davis (Brigham Young University)

Genomic research in the All of Us Researcher Workbench  Mary Davis (Brigham Young University) & Megan He (Vanderbilt University Medical Center)

Hands-on PheTK Demo  Tam Tran (Denny Lab)

Example: working through hypertension drug effectiveness  Slavi Goleva (Denny Lab)

Wednesday afternoon, May 22

Insights from the NIH All of Us Research Program - A Comprehensive Journey through Emerging Scientific Findings, Cross-Cohort Analyses, and Genomic Discovery

Genomic and other data are broadly available in the cloud-based platform, the All of Us Researcher Workbench. Here, researchers have discovered >275M previously unreported genetic variants, identified from data shared by nearly 250,000 All of Us participants. This extensive dataset, enriched with non-European genetic ancestry, opens new avenues for understanding genetic influences on health. Join us to delve into the emerging scientific impact and cross-cohort analyses.

This workshop is open to all registered attendees. 1:00 pm to 5:00 pm. 

Led by: Josh Denny, All of Us CEO

Speakers:

Josh Denny (All of Us Research, NIH) - Overview of All of Us

Jacob Keaton (Denny Lab) - BP PRS in All of Us

Peter Sauer (Denny Lab) - Clopidogrel & CYP2C19 

Henry Taylor (Collins lab) - T2D and OmicsPred PheWAS

Ariel Williams (Denny Lab) - APOL1 risk variants in All of Us

Chenjie Zeng (Denny Lab) - Rare variants/PheRS 

Mary Davis (Brigham Young University) - Multiple Sclerosis

Friday afternoon, May 24

Genomic research in the All of Us Researcher Workbench

Join us for a 2.5 hour session delving into how to utilize genomic data within the All of Us Researcher Workbench. Attendees will be able to actively learn through presenter led hands on activities. 

This workshop will be most beneficial to data scientists, bioinformaticians, health services researchers, epidemiologists, and genomics researchers at the introductory or intermediate level. It is recommended that attendees have basic familiarity with using R and/or Python programming languages and a working knowledge of basic genetic association study concepts and prior experience running a genetic association analysis. It is recommended that attendees bring a laptop and register with the All of Us Research Program (https://www.researchallofus.org/register/) prior to the start of the workshop to participate in all activities.

This workshop is open to all registered attendees. Tentatively set to run from 1:00 pm to 3:30 pm. 

Led by: Mary Davis, PhD Associate Professor, Brigham Young University and Megan He, PhD Scientific Research Project Manager, Vanderbilt University Medical Center

Speakers:

Mary Davis (Brigham Young University)  & Megan He (Vanderbilt University Medical Center) – Genomic research in the All of Us Researcher Workbench

Tam Tran (Denny Lab) - Hands-on PheTK Demo

Slavi Goleva (Denny Lab) - Example: working through hypertension drug effectiveness 

Day-of Parking

Day valet reduced rate is $15. To receive the special rate, please request a parking coupon at the conference registration desk.

Airport Transportation

Denver Airport  → Embassy Suites Denver Downtown Hotel Options: (Rome2Rio)

Ground Transportation Options at Denver Airport

• Light Rail to Downtown Union Station: The A Line provides travelers easy service from the airport to downtown Denver

• Ride App Services: Ride shares can be accessed on Island 5 of either side of the terminal (East or West)

• Taxi Services: Rates as well as a list of taxi cabs operating at the Denver Airport

Visit Denver Guide 

Urban sophistication meets outdoor adventure in Denver. Get acquainted with The Mile High City, including history, transportation and neighborhood guides. Welcome to Denver where 300 days of sunshine, a thriving cultural scene, diverse neighborhoods and natural beauty combine for the world's most spectacular playground. 

Eater Restaurant Guide:  The 38 Essential Restaurants in Denver

Arts and Music:

Denver Center for the Performing Arts

Everything from musicals to immersive experiences - May Performances and Tickets

Denver Art Museum

Denver Arts Festival, May 25 & 26

Only in Denver the Denver Area:

Catch a Colorado Rockies baseball game vs. the Philadelphia Phillies at 7:10 pm, Friday, May 24: Tickets

Meow Wolf Denver: Convergence Station 

Created by over 350 local and international artists, Convergence Station features four floors of Meow Wolf's most epic art to date, an interactive performance and event venue, and an unforgettable story of multiversal travel through alien worlds. [Often sells out in advance]

Union Station and Surrounding Area 

Nice restaurants and shops

Historic Denver Walking Tour 

Denver Mint Tours