Washington DC 2014

State of CHARGE

Christopher J. O'Donnell, MD, MPH NHLBI

Meet the Directors: Harnessing Global and Collaborative Science for Genomics Research for Common Diseases

• Gary H. Gibbons, MD NHLBI

• Richard J. Hodes, MD NIA

• Eric D. Green, MD NHGRI

• Errol G. Levy, BSc., MSc., MPP European Union

Genome Commons

• Eric Boerwinkle, Ph.D. University of Texas at Houston

Genome Sequencing

• Sudha Seshadri, MD., Boston University, "The Alzheimer Disease Sequencing Project Discovering rar risk and protective variants"

• Andrew P. Morris, Ph.D. University of Liverpool,  "The genetic architcture and pathophysiology of type 2 diabetes: lessons learned from sequencing, genotyping an dhigh-density imputation in the T2D-GENES" (not released)

Working Group Presentations

• Renal: Adrienne Tin, Ph.D. Johns Hopkins Bloomberg School of Public Health,  "Exome-wide sequencing analysis of kidney function"

• Epigenetics: Roby Joehanes, PhD., Institute for Aging, Harvard University, "Meta-analysis of epigenome-wide association studies between DNA methylation and smoking status"

• Glycemia-T2D: Shuai Wang, M.S., Boston University, "Gene-based tests with defined functional categories revealed novel findings"

Genomics in Multi-Ethnic Cohorts

• Donald W. Bowden, Ph.D., Wake Forest University,"Genetic analysis in populations with non-European ancestry: COGENT, MEDIA and AAGILE"

• Chao Agnes Hsiung, Ph.D., National Health Research Instititue in Taiwan, "TIACHI -Taiwan Cohort for Genetic Epidemiologic Studies of Cardiometabolic Disease and its Risk Factors in Chinese"

• Cathy C. Laurie, Ph.D., University of Washington, "An Introduction to the Hispanic Community Health Study / Study of Latinos"

• Timothy A. Thornton, Ph.D., University of Washington, "Statistical methosds for genetic analysis in admixed poputlations: Applications to the Hispanic Community Health Study / Study of Latinos"

Thursday November 13, 2014

Translational Genomics

• Stephen J. Chanock, M.D., National Cancer Insitute, "Genomic studies in cancer cohorts: current directions and collaborative opportunities"

• Mark Caufiled, M.D., Genomics England, "100,000 Whole Genomie Sequencing Project"

• Steven R. Cummings, M.D., University of California, San Francisco, "Translational Collaborations"

Omics

• Thomas J. Baranski, M.D., Ph.D., Washington University at St. Louis, "Drosophila model for functional genomics"

• Myriam Fornage, Ph.D., University of Texas at Houston, "Genome-wide DNA methylation studies in the CHARGE Consortium"

• Andrew D. Johnson, Ph.D. National Heart, Lung, and Blood Institute, "RNA expression: aging, genetics and beyond"

CHARGE-ENCODE Collaborations

• Leonard Lipovich, Ph.D., Wayne State University, "ENCODE-CHARGE Collaboration update: Integration of GWASNPology and LncRNAomics points to long non-coding RNA genes as direct causal candidates in type II diabetes, glycemia, and beyond"

• Robert J. Klein, Ph.D., Icahn School of Medicine at Mount Sinai, "CHARGE-ENCODE Collaborations"

Working Group Presenations

• CHD: Alanna C. Morrison, Ph.D., University of Texas at Houston, "Novel genes associated with myocardial infarction and coronary heart disease"

• JHS: Jin Li, B.S., University of North Carolina, Chapel Hill, "Genome-Wide Admixture and Association Study of Serum Iron, Ferritin, Transferrin Saturation, and Total Iron Binding Capacity in African Americans"

• Expression: Marjolein J. Peters, MSc., Erasmus Medical Center, "Identification of cis-and trans-acting variants in RNA sequencing data: a CHARGE-ENCODE collaboration"

CHARGE Golden Tiger Awards

Golden Tiger Awards were (hastily) presented on November 13th to the following CHARGE investigators:

Early Career Achievement:

• Sven van der Lee

• Bing Yu

Working Group Contributions:

• Robi Joehanes (Epigenetics)

• Misa Graff, Anne Justice, Thomas Winkler (Adiposity)

Working Group Leadership:

• Mark Goodarzi & Robert Scott (Diabetes-Glycemia)

• Joanne Murabito (Aging & Longevity + ReproGEN)

• Rozenn Lemaitre (Fatty Acids)

CHARGE Leadership:

• Myriam Fornage

• Susan Heckbert

CHARGE Contributions:

• Erika Enright

• Ann Walsh

Outstanding Poster:

• Frank J. A. van Rooij, “Trans-ethnic meta-analysis of erythrocyte traits”

• Lindsay M Reynolds, “Age-related variations in the methylome associated with gene expression in human monocytes and T cells.”